pregabalin + celecoxib + tramadol

This multimodal analgesic regimen is a combination of three distinct pharmaceutical agents used as a standard-of-care comparator in clinical trials conducted by Beijing Tiantan Hospital for the management of acute and subacute zoster-associated pain (herpes zoster). The regimen consists of **pregabalin**, a calcium channel alpha-2-delta ligand that modulates the release of excitatory neurotransmitters; **celecoxib**, a selective cyclooxygenase-2 (COX-2) inhibitor that reduces inflammatory prostaglandin synthesis; and **tramadol**, a centrally acting opioid agonist that also inhibits the reuptake of serotonin and norepinephrine. This combination is designed to target multiple pain pathways simultaneously, addressing both the neuropathic and inflammatory components of pain associated with varicella-zoster virus reactivation.

Other names

analgesicanalgesic-Beijing Tiantan Hospital-herpes zosterstandard oral analgesics