pregabalin + gabapentin

A combination therapy using two gabapentinoid medications (pregabalin and gabapentin) that act as α2δ ligands. While not binding directly to GABA receptors, they modulate pain signaling pathways in the nervous system[1]. The combination may provide synergistic effects in pain control, allowing for reduced dosing of each agent while potentially enhancing therapeutic response[1][4]. This approach is sometimes used when monotherapy fails to provide adequate pain relief, particularly in conditions like postherpetic neuralgia[4]. Pregabalin exhibits first-order pharmacokinetics with faster onset and stronger correlation between concentration and dose, reaching maximum concentration within an hour. Gabapentin exhibits zero-order pharmacokinetics with decreased bioavailability at higher doses and takes 3-4 hours to reach maximum concentration[3][4].

Brand names

NeurontinGraliseHorizantLyricaLyrica CR