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pregabalin + nortriptyline
- Development stage
- Unknown
- Lead developer
- Vanprom Lifesciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Gabcure 75 NT is a fixed-dose combination oral tablet developed and marketed by Vanprom Lifesciences for the management of various neuropathic pain conditions, including diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury-related pain. The formulation contains 75 mg of pregabalin, a gabapentinoid that binds to the alpha-2-delta subunit of voltage-gated calcium channels to modulate the release of excitatory neurotransmitters, and 10 mg of nortriptyline, a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin. By targeting both the ascending and descending pain pathways, Gabcure 75 NT provides a synergistic approach to reducing chronic nerve-related pain perception and signal transmission.
- Brand names
- Gabcure 75 NTGabcure75 NTGabcure-75 NTGabcure 75-NTGabcure75-NTGabcure-75-NT
- Other names
- Pregabalin 75mg + Nortriptyline 10mg
02
Targets
SERT (Sodium-dependent serotonin transporter)CACNA2D2 (α2δ-2)NET (Norepinephrine Transporter)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)
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