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pregabalin + nortriptyline + methylcobalamin
- Development stage
- Unknown
- Lead developer
- Prospera Biotech
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qnerve-NT is a fixed-dose combination pharmaceutical product marketed by Tabq Therapeutics, primarily indicated for the management of neuropathic pain. The formulation typically consists of three active components: **pregabalin**, **nortriptyline**, and **methylcobalamin**. Pregabalin is an anticonvulsant that acts as a ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, thereby reducing the release of excitatory neurotransmitters. Nortriptyline is a tricyclic antidepressant that enhances descending pain inhibitory pathways by inhibiting the reuptake of norepinephrine and serotonin. Methylcobalamin, a neurologically active form of vitamin B12, supports nerve health by promoting the synthesis of the myelin sheath and aiding in nerve cell regeneration. This synergistic combination is commonly used in the Indian pharmaceutical market to treat chronic nerve pain conditions such as diabetic peripheral neuropathy and postherpetic neuralgia.
- Brand names
- Qnerve-NT
- Other names
- pregabalin/nortriptyline/methylcobalamin combination
02
Targets
CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)M1 (Muscarinic acetylcholine receptor M1)SERT (Sodium-dependent serotonin transporter)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)NET (Norepinephrine Transporter)CACNA2D2 (α2δ-2)
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