pregabalin + sertraline

Pregabalin + sertraline is a combination of two pharmaceutical drugs used together, typically in clinical practice rather than as a fixed-dose commercial product. Pregabalin is an anticonvulsant and analgesic that binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system, reducing neurotransmitter release and thereby decreasing neuronal excitability. It is primarily indicated for neuropathic pain, fibromyalgia, partial seizures (as adjunctive therapy), generalized anxiety disorder (GAD), and other conditions[2][5][6]. Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant that increases synaptic serotonin levels by inhibiting its reuptake into presynaptic neurons. It is mainly used to treat major depressive disorder, panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and sometimes off-label for neuropathic pain or fibromyalgia[3]. The combination may be prescribed when monotherapy with either agent does not provide sufficient symptom control—such as in cases of comorbid depression/anxiety with chronic pain syndromes or fibromyalgia[3]. However, there are potential pharmacodynamic interactions between these drugs; both can cause central nervous system depression leading to increased risk of drowsiness or impaired coordination. Caution should be exercised due to additive side effects such as dizziness or sedation[1][4][8].

Other names

Lyrica + Zoloftpregabalin and sertralineLyrica and Zoloft