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Preparation Combination NRT + Standard Duration Combination NRT
- Development stage
- Phase 4
- Lead developer
- University of Wisconsin–Madison
- Modality
- Small Molecules
- Administration
- Transdermal, Oral
01
Overview
This specific treatment regimen consists of a combination of nicotine replacement therapies (NRT), specifically the nicotine patch and nicotine mini-lozenge, administered over a 16-week period. The Preparation component involves starting the medication 4 weeks prior to the target quit date (pre-quit), while the Standard Duration component covers 12 weeks of treatment following the quit date. This approach is being evaluated by the University of Wisconsin, Madison, as part of the Multiphase Optimization Strategy (MOST) to optimize chronic care for smokers. Nicotine replacement therapy works by providing a controlled dose of nicotine to reduce withdrawal symptoms and cravings associated with smoking cessation, acting as an agonist at nicotinic acetylcholine receptors.
- Other names
- Preparation Combination NRT and Standard Duration Combination NRTC-NRT (16 weeks)Nicotine patch + nicotine mini-lozenge (16 weeks)
02
Targets
α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)CHRNA7 (α7 nicotinic receptor)
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