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PRF + polyhexamethylene biguanide + macrogol

Development stage
Preclinical
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Topical
01

Overview

This is a combination product containing three components: - **PRF** (likely "poloxamer 188," also known as Pluronic F68): a nonionic surfactant and excipient used in pharmaceutical formulations for its membrane-protective, solubilizing, and emulsifying properties. It has demonstrated potential therapeutic effects in cell membrane repair and neuroprotection, as well as applications in burn wound management[1][2][3][4][5][7]. - **PHMB** (polyhexamethylene biguanide): an antimicrobial polymer widely used for its broad-spectrum antibacterial activity. It is commonly found in wound care products, disinfectants, and contact lens solutions. - **Macrogol** (polyethylene glycol/PEG): an osmotic laxative used to treat constipation by increasing water content in the stool. It is also employed as an excipient to enhance drug solubility and stability[6][8]. The combination of these agents suggests use in topical or wound care settings—PRF for tissue protection/healing support, PHMB for infection control, and macrogol for moisture retention or formulation purposes.

Other names
PRF + PHMB + macrogolPRF + polyhexamethylene biguanide + polyethylene glycol
02

Targets

Luminal water in the colon and colonic osmotic environment

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