prodigiosin + selenium nanoparticles

Prodigiosin + selenium nanoparticles is a nanoformulation combining prodigiosin, a red tripyrrole pigment produced by bacteria such as *Serratia marcescens* and *Serratia rubidaea*, with selenium nanoparticles (SeNPs). This combination leverages the anticancer, antimicrobial, anti-inflammatory, and immunosuppressive properties of prodigiosin along with the neuroprotective and antioxidant properties of selenium. The synthesis involves mixing sodium selenite with prodigiosin solution under magnetic stirring for 24 hours, followed by lyophilization. The resulting nanoparticles are typically spherical with an average size of approximately 121.7 nm and demonstrate moderate stability with a zeta potential of -23.3 mV. The nanoformulation exhibits amorphous characteristics rather than crystalline structure. Prodigiosin acts through multiple mechanisms including suppression of lipopolysaccharide-induced inflammatory responses by inhibiting c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and nuclear factor kappa B (NF-κB) activation. Selenium nanoparticles contribute neuroprotective effects through modulation of the electron transport chain, neurogenesis regulation, calcium transport in neurons, and maintenance of redox balance. The combination has been investigated for neuroprotective applications and shows enhanced therapeutic potential compared to either component alone due to the synergistic effects and improved bioavailability provided by the nanoparticle formulation.

Other names

PDGs-SeNPsprodigiosin-loaded selenium nanoparticles