progesterone + estradiol

Progesterone + estradiol is a combination hormonal therapy used for luteal phase support (LPS) in assisted reproductive technology (ART), specifically In Vitro Fertilization (IVF). Progesterone is a steroid hormone essential for the secretory transformation of the endometrium, which is necessary for embryo implantation and the maintenance of early pregnancy. Estradiol is often co-administered to maintain serum estrogen levels during the luteal phase, particularly in protocols where endogenous production may be compromised by pituitary suppression or specific trigger agents. In the clinical research conducted by Peter Humaidan, this combination typically serves as the standard-of-care control treatment against which experimental protocols, such as GnRHa triggers followed by low-dose hCG support, are compared to evaluate pregnancy outcomes and the risk of ovarian hyperstimulation syndrome (OHSS).

Brand names

CrinoneEstrofem

Other names

Progesterone and EstradiolExogenous progesterone and estradiol support