progesterone + statins

Progesterone + statins refers to a combination therapy regimen being investigated by Peking University People's Hospital for the fertility-preserving treatment of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC). The treatment involves the administration of a progesterone-based regimen (such as oral medroxyprogesterone acetate or a levonorgestrel-releasing intrauterine system, sometimes combined with a GnRH agonist) alongside a statin (HMG-CoA reductase inhibitor), such as rosuvastatin, atorvastatin, or pitavastatin. This approach is based on research indicating that cholesterol accumulation in endometrial tissues can compete with progestins for binding to the progesterone receptor B (PRB), thereby inducing progestin resistance. By inhibiting HMG-CoA reductase, statins reduce intracellular cholesterol levels, potentially restoring progestin sensitivity and improving clinical outcomes in young women seeking to avoid hysterectomy.

Other names

Progesterone Therapeutic Regimen Plus StatinsProgesterone plus Statins in AEH and EEC