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promethazine hydrochloride + phenylephrine hydrochloride
- Development stage
- Unknown
- Lead developer
- Genus Lifesciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Promethazine hydrochloride + phenylephrine hydrochloride is an FDA-approved combination oral solution indicated for the temporary relief of upper respiratory symptoms, including nasal congestion, associated with allergic rhinitis and the common cold. The formulation contains promethazine hydrochloride, a phenothiazine-derivative H1 receptor antagonist with sedative and antiemetic properties, and phenylephrine hydrochloride, a sympathomimetic amine that functions as a nasal decongestant through alpha-adrenergic receptor agonism and subsequent vasoconstriction. Distributed by Genus Lifesciences, this small molecule combination has historically been marketed under brand names such as Phenergan VC and Pherazine VC.
- Brand names
- Phenergan VCPherazine VC
- Other names
- promethazine hydrochloride and phenylephrine hydrochloride
02
Targets
HRH1 (Histamine H1 Receptor)ADRA1A (α1A)mAChR (Muscarinic acetylcholine receptors)DRD2 (Dopamine D2 Receptor)
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