Drug intelligence / Profile preview

propofol + etomidate + sufentanil

Development stage
Unknown
Lead developer
AkzoNobel
Modality
Small Molecules
Administration
Intravenous
01

Overview

This is a combination of three intravenous anesthetic and analgesic agents: propofol, etomidate, and sufentanil. Propofol is a short-acting sedative-hypnotic used for induction and maintenance of general anesthesia, acting primarily as a positive allosteric modulator at the GABA-A receptor[2][3][4]. Etomidate is also a nonbarbiturate sedative-hypnotic used for rapid induction of anesthesia, with minimal cardiovascular effects; it acts mainly by enhancing GABAergic neurotransmission[3]. Sufentanil is an ultra-potent synthetic opioid analgesic that acts as an agonist at the mu-opioid receptor to provide profound analgesia and supplement anesthesia[1]. This combination may be used in clinical settings requiring rapid sequence induction or deep sedation with strong analgesia.

Other names
丙泊酚 + 依托咪酯 + 舒芬太尼
02

Targets

GABRR (GABA-A receptor subunit rho)MOR (Mu opioid receptor)

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