propofol + remifentanil

Propofol + remifentanil is a pharmacological combination frequently utilized for total intravenous anesthesia (TIVA) and monitored anesthesia care (MAC). Propofol is a short-acting intravenous hypnotic agent that acts as a positive allosteric modulator of the GABA-A receptor, leading to central nervous system depression and sedation. Remifentanil is a potent, ultra-short-acting synthetic mu-opioid receptor agonist that provides intense analgesia with a rapid onset and offset, primarily due to its metabolism by non-specific plasma and tissue esterases. In the context of clinical research at Erasme University Hospital, this combination is used as the standard sedative regimen for patients undergoing oocyte retrieval during in vitro fertilization (IVF) procedures, often administered via target-controlled infusion (TCI) to maintain precise effect-site concentrations.

Brand names

MIXTIVA

Other names

propofol-remifentanil sedationpropofol + remifentanil-Erasme University Hospital