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propofol + succinylcholine + sevoflurane

Development stage: Unknown
Modality: Small Molecules
Administration: Intravenous, Inhalation

Overview

A combination anesthetic regimen consisting of propofol (intravenous anesthetic), succinylcholine (neuromuscular blocking agent), and sevoflurane (inhalational anesthetic). This combination is used for induction and maintenance of general anesthesia, particularly for facilitating endotracheal intubation. ## Pharmacological Properties - **Propofol**: Intravenous anesthetic for induction and maintenance. - **Suxamethonium (Succinylcholine)**: Depolarizing neuromuscular blocking agent for muscle relaxation. - **Sevoflurane**: Inhalational anesthetic for induction and maintenance. ## Pharmacodynamic Interactions - Propofol and sevoflurane interact additively for loss of consciousness and immobility, suggesting common mechanisms (e.g., GABA-A receptors). - May produce a deeper anesthetic state than single agents. - Provides superior intubating conditions compared to single agents. ## Hemodynamic Effects - Lower peak mean arterial pressure (MAP) compared to sevoflurane alone. - Provides better hemodynamic stability during induction and intubation. ## Recovery Characteristics - May result in longer recovery time due to deeper anesthesia. - May be disadvantageous for seizure duration and recovery in electroconvulsive therapy (ECT).

Brand names: DiprivanAnectineQuelicinUltaneSevoraneCarbocaine
Other names: propofol + suxamethonium + sevoflurane

Targets

Nicotinic Acetylcholine Receptor

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