Drug intelligence / Profile preview

propofol + thiopental

Development stage
Unknown
Lead developer
AkzoNobel
Modality
Small Molecules
Administration
Intravenous
01

Overview

Propofol and thiopental are two intravenous anesthetic agents that can be used in combination or as alternatives to each other. Propofol (2,6-diisopropylphenol) is a rapid-onset, short-acting intravenous anesthetic used for induction and maintenance of general anesthesia. Thiopental (also known as thiopental sodium or thiopentone) is a short-acting barbiturate used for anesthesia induction. When used together, they have been found to have synergistic hypnotic effects. The combination may be used in specific clinical scenarios, though they are more commonly used as alternatives to each other rather than in combination.

Other names
thiopental sodium + propofolthiopentone + propofol
02

Targets

GABRR (GABA-A receptor subunit rho)NMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)

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