propofol + tropisetron

"P + T" refers to the combination of the intravenous anesthetic **propofol** and the selective 5-HT3 receptor antagonist **tropisetron**, specifically as utilized in a clinical trial conducted by Huazhong University of Science and Technology. Propofol is a short-acting anesthetic agent that acts as a positive allosteric modulator of GABA-A receptors, while tropisetron is primarily indicated for the prevention of postoperative nausea and vomiting (PONV). In this specific trial context (NCT01411306), the combination was evaluated for its potential analgesic effects on postoperative pain in women undergoing gynaecological laparoscopy. The study aimed to determine if the addition of tropisetron to a propofol-based anesthetic regimen could reduce nociceptive processing, potentially through the modulation of 5-HT3A receptors involved in pain pathways.

Other names

Propofol and Tropisetron