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prostaglandin + timolol (TODDD)
- Development stage
- Preclinical
- Lead developer
- Amorphex Therapeutics
- Modality
- Small Molecules
- Administration
- Transocular
01
Overview
Amorphex Therapeutics is developing a combination of a prostaglandin analogue and timolol maleate delivered via their proprietary Transocular Drug Delivery Device (TODDD™). The TODDD™ is a soft, flexible, non-invasive ring-like insert placed under the eyelid (transocular/conjunctival fornix) designed for sustained release of medication over several months. This combination therapy targets moderate glaucoma by utilizing two distinct mechanisms: the prostaglandin analogue increases uveoscleral outflow of aqueous humor, while timolol, a non-selective beta-adrenergic antagonist, decreases aqueous humor production. This dual-action approach aims to improve patient compliance and provide consistent intraocular pressure (IOP) control compared to daily eye drops.
- Brand names
- TODDD
- Other names
- TODDD + Prostaglandin and Timolol
02
Targets
ADRB1 (β1)ADRB2 (β2)PTGFR (Prostaglandin F2 alpha receptor)
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