PRP + PL

PRP + PL is an autologous orthobiologic combination therapy developed by Regenexx, LLC, for the treatment of axial lower back pain associated with multifidus muscle atrophy. The treatment protocol involves a multi-modal injection approach: autologous platelet-rich plasma (PRP) is injected into the lumbar multifidus muscle and facet joints, while autologous platelet lysate (PL) is administered into the epidural space. PRP provides a concentrated source of platelets that release a variety of growth factors (such as PDGF, TGF-β, and VEGF) over time to promote tissue repair and angiogenesis. Platelet lysate, created by lysing platelets to immediately release their internal growth factors and enzymes, provides a more rapid anti-inflammatory and regenerative effect. This combination therapy is designed to reverse muscle atrophy and stabilize the spine by stimulating the body's natural healing mechanisms in the affected spinal structures.

Other names

PRP and PL Combo treatmentautologous platelet-rich plasma and platelet lysate