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PRS + Akkermansia muciniphila
- Development stage
- Preclinical
- Lead developer
- Akkermansia
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
A synbiotic combination consisting of the prebiotic Puerariae lobatae Radix-resistant starch (PRS) and the probiotic *Akkermansia muciniphila* (AKK). This combination is being investigated for the treatment of ischemic stroke by modulating the gut-brain axis. PRS selectively enriches AKK, which produces the metabolite indole lactic acid (ILA). ILA acts as a ligand for the aryl hydrocarbon receptor (AhR) and activates the Nrf2 signaling pathway. This activation leads to the upregulation of ferroptosis-inhibiting proteins, specifically SLC7A11 and GPX4, thereby reducing neuronal damage and intestinal injury following an ischemic stroke. Preclinical studies in rat models have shown that this synbiotic approach is more effective than either component alone in alleviating stroke-induced damage.
- Other names
- Puerariae lobatae Radix-resistant starch + Akkermansia muciniphilaPRS + AKKPuerariae lobatae Radix-resistant starch + Akkermansia muciniphila synbiotic
02
Targets
TLR2 (Toll-like Receptor 2)ICAM2 (ICAM-2)TLR4 (Toll-like receptor 4)
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