psilocybin + psychotherapy

Psilocybin is a naturally occurring psychedelic small molecule being investigated by the Roswell Park Comprehensive Cancer Center in a Phase II clinical trial for the treatment of chronic cancer pain. This specific therapeutic approach utilizes a novel 'micro-dosing' regimen, where patients receive multiple low doses of psilocybin weekly rather than a single high dose. The drug is administered in conjunction with 'meaning-based' psychotherapy to address 'total pain,' which encompasses the psychological, spiritual, and social dimensions of the patient's experience. Psilocybin acts primarily as an agonist at serotonin receptors, particularly the 5-HT2A subtype, which is believed to modulate neural pathways associated with pain perception, existential distress, and emotional regulation in patients with advanced cancer.

Other names

psilocybinpsilocybine4-phosphoryloxy-N,N-dimethyltryptamineLow-Dose Psilocybin Therapy