Drug intelligence / Profile preview

psyllium + senna + phenolphthalein

Development stage
Discontinued
Lead developer
MADAUS
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Agiolax + phenolphthalein is a combination laxative that integrates bulk-forming, stimulant, and contact laxative properties. The Agiolax component typically consists of *Plantago ovata* (psyllium) seeds and husks, which act as bulk-forming agents by absorbing water and increasing stool volume, and *Senna* (containing sennosides), which stimulates colonic peristalsis. Phenolphthalein is a potent stimulant laxative that acts directly on the intestinal mucosa to increase motor activity and inhibit water absorption. While Agiolax remains a widely used herbal laxative, the addition of phenolphthalein was common in older formulations before phenolphthalein was largely phased out in many jurisdictions due to concerns regarding its potential carcinogenicity. The combination was primarily indicated for the short-term treatment of acute or chronic constipation.

Brand names
Agiolax mit PhenolphthaleinAgiolax with Phenolphthalein
Other names
Agiolax + phenolphthalein
02

Targets

ATP1A (Sodium/potassium-transporting ATPase)

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