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pu yang wan wu tang + pentoxifylline
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pu Yang Wan Wu Tang + pentoxifylline is a combination of a traditional Chinese herbal formula (Pu Yang Wan Wu Tang) and the pharmaceutical drug pentoxifylline. Pentoxifylline is a methylxanthine derivative and hemorheological agent that improves blood flow by decreasing blood viscosity, increasing erythrocyte flexibility, reducing plasma fibrinogen, inhibiting neutrophil activation, and suppressing platelet aggregation. It acts primarily as a non-specific phosphodiesterase inhibitor (mainly PDE III/IV), leading to increased intracellular cAMP levels and has additional anti-inflammatory effects. Pentoxifylline is approved for the treatment of intermittent claudication due to chronic occlusive arterial disease of the limbs[1][2][5]. Pu Yang Wan Wu Tang is presumed to be an herbal formulation used in traditional Chinese medicine; its specific composition and mechanism are not well-documented in Western medical literature.
- Other names
- Pu Yang Wan Wu Tang + pentoxifylline
02
Targets
ADORA2A (Adenosine A₂A Receptor)PDE3PDE4 (Phosphodiesterase 4A1)
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