Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
puerarin 6''-O-xyloside
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Puerarin 6''-O-xyloside (P6OX) is a natural isoflavone glycoside isolated from the roots of *Pueraria lobata* (kudzu root). As a small molecule research chemical, it has demonstrated significant pharmacological potential in preclinical models of cancer, osteoporosis, and metabolic disease. Its antitumor mechanism involves the induction of the mitochondria-mediated apoptosis pathway, characterized by the upregulation of pro-apoptotic proteins such as Bax and caspases (caspase-3, -7, and -9) and the downregulation of the anti-apoptotic protein Bcl-2. Furthermore, it acts as a histone deacetylase (HDAC) inhibitor and a PPARα agonist, the latter of which facilitates fatty acid oxidation to alleviate postmenopausal lipid metabolic disorders. While it is widely used in scientific investigation for its phytoestrogenic and anti-osteoporotic properties, it is not currently approved for human therapeutic use.
- Other names
- Puerarin 6''-O-beta-D-xylopyranosidePuerarin 6''-xyloside
02
Targets
PPARA (Peroxisome proliferator-activated receptor alpha)KDM6B (Lysine-specific demethylase 6B)
Beyond the preview
Go deeper on puerarin 6''-O-xyloside.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on puerarin 6''-O-xyloside.