pulsed dye laser + Kligman's trio

Pulsed dye laser + Kligman's trio is a combination therapeutic regimen investigated for the treatment of melasma, particularly in patients with darker skin types (Fitzpatrick types V and VI). The regimen consists of a topical triple-combination cream, known as Kligman's Trio, which typically contains hydroquinone, retinoic acid (tretinoin), and a corticosteroid, used in conjunction with pulsed dye laser (PDL) sessions. The topical components work synergistically to inhibit melanin production, accelerate epidermal turnover, and minimize inflammation, while the PDL targets the vascular abnormalities often present in melasma lesions. This combination approach aims to enhance clinical efficacy and reduce the risk of post-inflammatory hyperpigmentation compared to topical therapy alone.

Other names

Kligman's TrioKligman's formulaKligman's preparationstabilized Kligman preparation