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PVM + UFT (Cisplatin + Mitomycin C + Vindesine + Uracil + Tegafur)
- Development stage
- Unknown
- Lead developer
- Michigan State University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination involves **cisplatin**, a platinum-based antineoplastic drug that works by forming DNA adducts, leading to apoptosis; **mitomycin C**, an alkylating agent that cross-links DNA; **vindesine**, a vinca alkaloid that inhibits microtubule assembly; **tegafur**, a prodrug of 5-fluorouracil, which interferes with DNA synthesis; and **uracil**, which enhances the bioavailability of tegafur. This regimen is used in the treatment of non-small cell lung cancer (NSCLC).
- Other names
- PVM chemotherapy followed by UFT
02
Targets
TUBB (Tubulin (alpha and beta subunits))DPYD (Dihydropyrimidine dehydrogenase)DNATS (Thymidylate synthase)
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