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pyridoxal 5'-phosphate
- Development stage
- Unknown
- Lead developer
- Colorado State University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Pyridoxal 5'-phosphate (PLP) is the active metabolite of Vitamin B6 and is being investigated by Colorado State University as a potential ATP receptor antagonist. Specifically, research focuses on its ability to act as a P2Y2 receptor antagonist to study the role of ATP in vasodilation during exercise and hypoxia. In a mechanistic clinical trial (NCT03738943), PLP is administered via infusion to healthy young adults to evaluate its effectiveness in blocking ATP-mediated blood flow increases, which may help explain reduced vascular function in aging populations.
- Other names
- Pyridoxal-5-PhosphatePyridoxal5-PhosphatePyridoxal 5-PhosphateVitamin B6 active metabolite
02
Targets
P2RX1 (Purinergic receptor P2X 1)P2RX2 (Purinergic receptor P2X 2)P2RX4 (P2X Purinoceptor 4)P2RY2 (P2Y Purinoceptor 2)
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