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QDP-PSA-011 + antibiotic
- Development stage
- Preclinical
- Lead developer
- Ottawa Hospital Research Institute
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics, Small Molecules
- Administration
- Intraarticular
01
Overview
QDP-PSA-011 + antibiotic is an experimental combination therapy being investigated by the Ottawa Hospital Research Institute for the treatment of chronic periprosthetic joint infection (PJI). The therapy consists of a personalized bacteriophage cocktail, QDP-PSA-011, administered in conjunction with antibiotics. It is being evaluated in a single-patient study for an individual with a hip PJI caused by a multidrug-resistant (MDR) strain of *Pseudomonas aeruginosa* for whom all other treatment options have been exhausted. The therapeutic approach aims to leverage a synergistic antibacterial effect between the bacteriophages and antibiotics to overcome resistance and resolve the chronic infection.
- Other names
- Combining bacteriophage therapy with antibiotics for a case with hip PJI
02
Targets
P. aeruginosa (Pseudomonas aeruginosa)
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