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Qinzhuliangxue granules + loratadine

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Qinzhuliangxue granules + loratadine is a combination therapy consisting of a traditional Chinese medicine (TCM) herbal formulation (Qinzhuliangxue, also known as QZLX) and the second-generation antihistamine loratadine. - **Qinzhuliangxue granules** are composed of several herbs including Scutellaria baicalensis (Huang Qin), mother-of-pearl, peony bark, Lithospermum, Saposhnikovia, oyster shell, and magnetite. The formula is traditionally used to treat eczema and other inflammatory skin conditions by reducing "heat" and dampness according to TCM theory. Modern studies suggest it has anti-inflammatory, antioxidant, immunomodulatory, and antiallergic effects[6][7][8][9]. - **Loratadine** is an oral small molecule antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is widely used for symptomatic relief of allergic rhinitis and urticaria by blocking histamine-mediated symptoms such as itching and swelling[3]. The combination aims to leverage both the anti-inflammatory/immunomodulatory properties of the herbal components with the rapid symptom control provided by loratadine's antihistaminic action. This approach may be particularly relevant in dermatologic conditions like eczema or atopic dermatitis where both immune dysregulation ("heat," inflammation) and allergic symptoms are present[2][6][7].

Other names
Qinzhuliangxue granules and loratadineQZLX granules + loratadine
02

Targets

HRH1 (Histamine H1 Receptor)

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