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Qishen Yiqi Dropping Pills + targeted therapy
- Development stage
- Unknown
- Lead developer
- Tasly Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Qishen Yiqi Dropping Pills + targeted therapy refers to a combination treatment regimen being evaluated for severe pulmonary hypertension. Qishen Yiqi Dropping Pills (QSYQ) is a Chinese patent medicine approved by the NMPA for cardiovascular conditions, containing extracts from *Astragalus membranaceus*, *Salvia miltiorrhiza*, *Panax notoginseng*, and *Dalbergia odorifera*. The targeted therapy component consists of standard-of-care agents for pulmonary arterial hypertension (PAH), such as endothelin receptor antagonists (ERAs), phosphodiesterase type 5 (PDE5) inhibitors, or soluble guanylate cyclase (sGC) stimulators. This combination aims to provide synergistic effects by combining the vasodilatory and remodeling-inhibitory actions of targeted drugs with the cardioprotective, anti-inflammatory, and microcirculation-enhancing properties of QSYQ. Clinical research, such as trials led by Guangdong Provincial People's Hospital, focuses on improving exercise capacity, heart function, and quality of life in patients with severe PAH.
- Other names
- Qishen Yiqi Diwan
02
Targets
ETR (Endothelin receptor)POSTN (Periostin protein)sGC (Soluble Guanylyl Cyclase)PDE6 (Phosphodiesterase 6)PDE5 (Phosphodiesterase 5A)
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