Drug intelligence / Profile preview

quercetin + resveratrol

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

A combination product consisting of **quercetin** and **resveratrol**, both naturally occurring polyphenolic compounds. This combination has been studied primarily for its potential **anticancer activity**, particularly in preclinical settings for oral cancer cells, where it induces **cell growth inhibition**, **S-phase cell cycle arrest**, **DNA damage**, and **apoptosis**. The combination downregulates histone deacetylases (HDAC1, HDAC3, HDAC8) and modulates apoptosis-related proteins like PARP1 and Bax. While both compounds are individually known for antioxidant, anti-inflammatory, and chemopreventive properties, the combination is reported to produce additive or synergistic biological effects, especially in malignant cells. The use is generally as a **phytochemical or dietary supplement**, and no pharmaceutical company or official drug name is associated with QRu + resveratrol in regulated drug databases[1].

Other names
QRu + resveratrol
02

Targets

KDM1A (LSD1)HDAC1 (Histone Deacetylase 1)HDAC8 (Histone Deacetylase 8)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)

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