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R&D115
- Development stage
- Preclinical
- Lead developer
- Bostal Pharma
- Modality
- Small Molecules
- Administration
- Intramuscular
01
Overview
R&D115 is a long-acting injectable (LAI) formulation of brexpiprazole, a small molecule atypical antipsychotic, being developed by Bostal Pharma. Utilizing the 505(b)(2) regulatory pathway, R&D115 is designed to provide sustained therapeutic levels of brexpiprazole over extended periods, with specific versions targeting 3-month (3M) and 6-month (6M) dosing intervals. The drug's mechanism of action involves partial agonism at dopamine D2 and serotonin 5-HT1A receptors, combined with antagonism at serotonin 5-HT2A receptors. It is primarily indicated for the treatment of schizophrenia and bipolar I disorder, aiming to improve patient compliance and clinical outcomes through infrequent intramuscular administration.
- Other names
- R&D115 LAIR&D115 LAI 3MR&D115 LAI 6MBrexpiprazole LAI
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))DRD2 (Dopamine D2 Receptor)
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