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RAB11 inhibitor (small molecule)
- Development stage
- Preclinical
- Lead developer
- Atomwise
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
RAB11 inhibitor (small molecule) refers to a class of small molecule compounds designed to inhibit the activity of RAB11, a small monomeric GTPase (specifically a Rab GTPase) that regulates key cellular processes including endocytic recycling, exocytosis, and autophagy. Developed through a collaboration between the University of Freiburg and Atomwise using the AtomNet AI platform, these inhibitors (such as Rab11-inhibitor-D5, Rab11-inhibitor-B6, and Rab11-inhibitor-D6) are being investigated for the treatment of RAB11-associated disorders, particularly nephrotic syndrome caused by TBC1D8B mutations, which lead to disinhibition of RAB11.
- Other names
- RAB11 inhibitorRAB-11 inhibitorRAB 11 inhibitorRAB11 inhibitorsRAB-11 inhibitorsRAB 11 inhibitorsRab11-inhibitor-B6Rab-11-inhibitor-B6Rab 11-inhibitor-B6Rab11-inhibitor-D5Rab-11-inhibitor-D5Rab 11-inhibitor-D5Rab11-inhibitor-D6Rab-11-inhibitor-D6Rab 11-inhibitor-D6
02
Targets
RAB11A (Ras-related protein Rab-11A)
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