Drug intelligence / Profile preview

rabies vaccine (Chengdu Bioteque)

Development stage
Approved
Lead developer
Sinovac Biotech
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The lyophilized human rabies vaccine (serum-free Vero cells) is an inactivated viral vaccine developed by Chengdu Bioteque for the prevention of rabies. It is produced using a serum-free Vero cell culture process, which aims to improve safety by eliminating bovine-derived components and reducing the risk of allergic reactions or contamination. The vaccine is typically administered via the Essen 5-dose regimen (days 0, 3, 7, 14, and 28) or the Zagreb 4-dose regimen. It works by stimulating the production of neutralizing antibodies against the rabies virus, providing active immunity. As of 2024, it is in Phase III clinical development in China to evaluate batch consistency and safety.

Other names
lyophilized human rabies vaccinelyophilized human rabies vaccine (serum-free Vero cells)serum-free Vero cell rabies vaccine
02

Targets

BCR-RVG (B-cell receptor specific for rabies virus glycoprotein)MHC I (MHC class I})MHC II (Major histocompatibility complex class II receptor)PRR (Pattern recognition receptors)RABV-G (Rabies virus glycoprotein)

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