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radium-223 dichloride + pembrolizumab
- Development stage
- Phase 2
- Lead developer
- Bayer
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Alpha Emitters → Radiopharmaceuticals, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
A combination therapy of **radium-223 dichloride**, an alpha-emitting radiopharmaceutical, and **pembrolizumab**, a programmed death-1 (PD-1) immune checkpoint inhibitor monoclonal antibody. Radium-223 selectively targets bone metastases with high-energy, short-range alpha-particles causing double-stranded DNA breaks in adjacent tumor cells, approved for metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastases and no known visceral metastatic disease. Pembrolizumab blocks PD-1, restoring T-cell–mediated antitumor immunity. The combination has been investigated in phase II trials for mCRPC to bone, with studies showing that pembrolizumab addition does not significantly enhance immune infiltration or clinical outcomes beyond radium-223 alone, but the regimen is generally well tolerated[1][3][5][7][9].
- Other names
- radium Ra 223 dichloride + pembrolizumabRa-223 + pembrolizumab
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)DNA
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