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raltitrexed + oxaliplatin (Second Affiliated Hospital of Zhejiang University School of Medicine)
- Development stage
- Unknown
- Lead developer
- Second Affiliated Hospital of Zhejiang University School of Medicine
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Raltitrexed + oxaliplatin (also known as the RALOX regimen) is a combination chemotherapy regimen being investigated for the treatment of advanced malignant biliary system tumors. Raltitrexed is a quinazoline folate analogue that functions as a potent and specific inhibitor of thymidylate synthase (TS), an enzyme essential for DNA synthesis. Oxaliplatin is a third-generation platinum-based antineoplastic agent that works by forming DNA adducts, which lead to intra-strand and inter-strand cross-links, effectively inhibiting DNA replication and transcription. This combination is primarily being studied as a second-line therapy in patients with unresectable advanced cholangiocarcinoma or gallbladder carcinoma who have failed first-line treatments.
- Other names
- raltitrexed + oxaplatin
02
Targets
DNATS (Thymidylate synthase)
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