Drug intelligence / Profile preview

ramipril + valsartan

Development stage
Preclinical
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

Ramipril + valsartan is a combination medication that combines an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and an angiotensin II receptor blocker (ARB) (valsartan). This combination is used to treat hypertension (high blood pressure) and heart failure. Ramipril works by preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, helping relax blood vessels and reduce blood pressure. Valsartan works by blocking the binding of angiotensin II to its receptors, preventing blood vessel constriction and lowering blood pressure. However, it should be noted that using ACE inhibitors and ARBs together is generally not recommended by medical guidelines due to increased risk of adverse effects without significant additional benefits.

02

Targets

ACE (Angiotensin Converting Enzyme)AGTR1 (Angiotensin II Type-1 receptor)

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