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RC148 + ABBV-400
- Development stage
- Phase 2
- Lead developer
- RemeGen
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
RC148 + ABBV-400 is an investigational combination therapy consisting of two biologics: RC148 (ABBV-1480), a bispecific antibody targeting programmed cell death protein 1 (PD-1) and vascular endothelial growth factor (VEGF), and ABBV-400 (telisotuzumab adizutecan), a c-Met-directed antibody-drug conjugate (ADC) carrying a topoisomerase 1 inhibitor payload. Developed through a partnership between RemeGen and AbbVie, this combination is designed to leverage the synergistic effects of immune checkpoint inhibition, anti-angiogenesis, and targeted cytotoxic delivery. By simultaneously blocking PD-1 and VEGF, RC148 enhances T-cell activation and normalizes tumor vasculature, which may facilitate better penetration and efficacy of ABBV-400 in c-Met-expressing tumor cells. The combination is currently being evaluated in Phase II clinical trials for advanced solid tumors, including non-squamous non-small cell lung cancer (NSCLC) and unresectable colorectal cancer (CRC).
- Other names
- ABBV-1480 + ABBV-400ABBV-1480 + Temab-AABBV-1480 + telisotuzumab adizutecanRC148 + Temab-ARC148 + telisotuzumab adizutecan
02
Targets
MET (Mesenchymal-epithelial transition factor receptor)PDCD1 (Programmed cell death protein 1 receptor)VEGFA (Vascular endothelial growth factor A)
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