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rdESAT-6 + rCFP-10

Development stage: Phase 1
Lead developer: Serum Institute of India
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration: Intradermal

Overview

rdESAT-6 + rCFP-10 is a recombinant fusion protein skin test reagent used for the diagnosis of latent tuberculosis infection. It contains two proteins from the Mycobacterium tuberculosis bacterium - recombinant dimeric ESAT-6 (rdESAT-6) and recombinant CFP-10 (rCFP-10) in a 1:1 ratio. This diagnostic tool offers enhanced specificity over traditional tuberculin skin tests, particularly in BCG-vaccinated individuals. The test is administered intradermally using the Mantoux technique, with results read by measuring induration at the injection site after 48-72 hours. An induration size over 5 millimeters indicates infection with M. tuberculosis.

Brand names: SIILTIBCYCy-Tb
Other names: Mycobacterium tuberculosis derived antigens

Targets

CFP-10 (Culture filtrate protein 10)ESAT-6 (Early secretory antigenic target 6)

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