Drug intelligence / Profile preview

rebif + ibuprofen

Development stage
Unknown
Lead developer
Merck
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Oral
01

Overview

This is a combination of two drugs: - **Rebif (interferon beta-1a):** A biologic immunomodulator used to treat relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. Interferon beta-1a works by modulating the immune response and reducing inflammation in the central nervous system. Its exact mechanism in MS is not fully understood but involves altering cytokine production and immune cell activity. - **Ibuprofen:** A nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation control. It acts primarily by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby decreasing prostaglandin synthesis. This combination is not a fixed-dose product but may be used together in clinical practice—ibuprofen is often recommended to help manage flu-like symptoms associated with interferon therapy[2][4]. There are no major direct interactions reported between these two drugs; however, both can affect liver function or blood counts when combined with other medications[6][7].

Brand names
MotrinAdvil
Other names
interferon beta-1a + ibuprofen
02

Targets

IFNAR (Immune system modulation via type I interferon receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

Beyond the preview

Go deeper on rebif + ibuprofen.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on rebif + ibuprofen.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call