Drug intelligence / Profile preview

recombinant growth hormone + amitriptyline + fluoxetine + tramadol

Development stage
Unknown
Lead developer
Merck
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Intramuscular, Oral, Intravenous
01

Overview

This is a combination of four separate medications: 1. **Recombinant growth hormone (somatropin)**: A synthetic form of human growth hormone that stimulates tissue growth, linear growth (height), and regulates protein, carbohydrate, lipid, and mineral metabolism. It's used to treat various growth disorders in children and adults. 2. **Amitriptyline**: A tricyclic antidepressant that works by increasing levels of serotonin and norepinephrine in the brain. 3. **Fluoxetine**: A selective serotonin reuptake inhibitor (SSRI) antidepressant that increases serotonin levels in the brain. 4. **Tramadol**: An opioid pain medication that works by binding to opioid receptors and inhibiting the reuptake of serotonin and norepinephrine. This specific combination is not a standard therapeutic regimen and would be highly unusual as these medications have different therapeutic purposes and potential serious interactions.

02

Targets

DAT (Dopamine plasma membrane transport protein)ADRA1A (α1A)HTR2A (Serotonin receptor 5-HT2A)SIGMAR1 (Sigma non-opioid intracellular receptor 1)GHR (Growth hormone receptor)SERT (Sodium-dependent serotonin transporter)HRH1 (Histamine H1 Receptor)HTR2C (5-hydroxytryptamine 2C receptor)NET (Norepinephrine Transporter)mAChR (Muscarinic acetylcholine receptors)

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