Drug intelligence / Profile preview

recombinant human chymotrypsin + dimethicone

Development stage
Preclinical
Lead developer
Wuhan Healthgen Biotechnology
Modality
Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
Administration
Topical
01

Overview

A combination drug comprising **recombinant human chymotrypsin**, a serine protease produced via recombinant DNA techniques, and **dimethicone**, a silicone-based anti-foaming agent. **Recombinant human chymotrypsin** acts by proteolytically cleaving peptide bonds in proteins, accelerating breakdown of necrotic tissue and aiding debridement in wounds or supporting recovery after trauma or surgery[1][2][3]. **Dimethicone** is commonly used for its anti-foaming properties and skin protectant effects, reducing surface tension and aiding in topical applications. The combination may be formulated for topical use, especially in wound care or as part of ointments, where the enzyme degrades proteinaceous debris and dimethicone helps maintain the integrity and moisture of the treatment area[3][4].

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