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recombinant human growth hormone + metformin
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Subcutaneous, Oral
01
Overview
A combination therapy consisting of recombinant human growth hormone (rhGH) and metformin. This combination has been studied for its effects on glucose metabolism, body composition, and potential anti-aging properties. The metformin component is specifically included to counter the diabetogenic (glucose-raising) effects of growth hormone. The combination has been investigated in the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial for thymus regeneration and potential biological age reversal.
- Other names
- rhGH + metforminhuman growth hormone + metforminHGH + metformin
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)GHR (Growth hormone receptor)
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