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recombinant vaccinia-CEA(6D)-TRICOM vaccine
- Development stage
- Phase 2
- Lead developer
- National Cancer Institute
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
A cancer vaccine consisting of a recombinant vaccinia virus vector encoding the tumor-associated antigen carcinoembryonic antigen (CEA) and a triad of costimulatory molecules—B7.1, ICAM‑1, and LFA‑3—collectively known as TRICOM. The vaccine is designed to stimulate the host immune system to mount a T-cell response against tumor cells expressing CEA. The inclusion of TRICOM enhances antitumor cytotoxic T lymphocyte responses compared to vaccines containing only CEA. It has been evaluated in clinical trials for patients with advanced solid tumors expressing CEA, demonstrating safety and immunogenicity with some evidence of clinical benefit[1][2][3][4][5].
- Other names
- CEA-TRICOMvaccinia-CEA(6D)-TRICOMrV (NYC)-CEANSC 710067NSC710067NSC-710067
02
Targets
ICAM1 (Intercellular Adhesion Molecule 1)CD58 (Leukocyte function-associated antigen 3)CEACAM5 (Carcinoembryonic antigen related cell adhesion molecule 5)CD80 (T-lymphocyte activation antigen CD80)
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