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Recombivax HB (Merck & Co.)

Development stage: Approved
Lead developer: Merck
Modality: Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

Recombivax HB is a recombinant hepatitis B vaccine consisting of purified hepatitis B surface antigen (HBsAg). It is produced using recombinant DNA technology where the antigen is expressed in yeast cells (Saccharomyces cerevisiae). The vaccine is indicated for the prevention of infection caused by all known subtypes of the hepatitis B virus (HBV) by stimulating the immune system to produce protective anti-HBs antibodies. The specific designation Recombivax-Rockefeller University-hepatitis B refers to the use of this vaccine in clinical research conducted by Rockefeller University, specifically a Phase 4 study (NCT01403116) evaluating the vaccine's efficacy and the innate immune response in patients with chronic hepatitis C virus (HCV) infection compared to healthy controls.

Brand names: Recombivax HBRecombivax
Other names: Hepatitis B Vaccine (Recombinant)HBsAg vaccine

Targets

HBsAg (Hepatitis B surface antigen)

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