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red blood cells + tranexamic acid + fibrinogen concentrate
- Development stage
- Unknown
- Lead developer
- Hospital Universitari de Girona Dr. Josep Trueta
- Modality
- Cell Therapies, Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Red blood cells + tranexamic acid + fibrinogen concentrate is a combination therapeutic regimen being investigated for the pre-hospital management of severe trauma and hemorrhagic shock. This protocol, evaluated in a pilot trial led by Cristina Martinez, involves the early administration of three critical components: red blood cells to restore oxygen delivery to tissues, tranexamic acid to act as an antifibrinolytic by inhibiting plasminogen activation, and fibrinogen concentrate to provide a concentrated source of clotting factor I. The goal of this intervention is to mitigate trauma-induced coagulopathy and improve survival by initiating definitive hemostatic resuscitation before the patient reaches the hospital, contrasting with traditional crystalloid-heavy resuscitation strategies.
- Other names
- RBC + TXA + FCPre-hospital RBC, Fibrinogen, and TXA
02
Targets
PLG (Plasminogen)
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