Drug intelligence / Profile preview

red yeast rice + omega-3

Development stage
Unknown
Lead developer
MEDA Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

This is a **combination dietary supplement** consisting of **red yeast rice** and **omega-3 polyunsaturated fatty acids (PUFAs)**, commonly formulated as fish oil. Red yeast rice provides monacolins, naturally occurring compounds that inhibit HMG-CoA reductase, the same target as statins, leading to reduced cholesterol synthesis in the liver. Omega-3 PUFAs, primarily EPA and DHA, exert anti-inflammatory effects and help lower triglyceride levels. In clinical trials, the combination has been shown to **improve lipid profiles** (lowering LDL-C, total cholesterol, apoB, and hsCRP) and endothelial function in subjects with mild hypercholesterolemia. Supplements may include other active ingredients such as coenzyme Q10, astaxanthin, folic acid, and vitamin B6, but the critical active components are red yeast rice (monacolins) and omega-3 PUFAs (EPA, DHA)[1][2][5].

Other names
red yeast rice plus omega-3red yeast rice and omega-3red yeast rice + fish oilred yeast rice + PUFAs
02

Targets

PPARA (Peroxisome proliferator-activated receptor alpha)FFAR4 (Free fatty acid receptor 4)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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