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Reference Dentifrice (1100 ppm fluoride as SnF2)
- Development stage
- Unknown
- Lead developer
- HALEON
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Reference Dentifrice (1100 ppm fluoride as SnF2) is a fluoride-containing toothpaste formulation used as a comparative control in clinical studies sponsored by Haleon, specifically for evaluating treatments for tooth erosion and enamel remineralization. This reference product contains 1100 parts per million (ppm) fluoride delivered in the form of stannous fluoride (SnF2). Stannous fluoride is a multi-benefit oral care agent recognized for its ability to provide anti-caries protection, reduce gingivitis, and alleviate dentin hypersensitivity. In the context of dental erosion, stannous ions deposit on the enamel surface to form a protective, acid-resistant barrier (stannous-rich pellicle), while fluoride ions promote the remineralization of acid-softened enamel by facilitating the formation of fluorapatite. In clinical trials, it serves as a benchmark to measure the efficacy of experimental formulations in protecting against acid challenges and aiding enamel recovery.
- Other names
- Reference Dentifrice1100 ppm F as SnF2 dentifriceStannous fluoride reference dentifrice
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