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resveratrol + delta-tocotrienol
- Development stage
- Unknown
- Lead developer
- American River Nutrition
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Resveratrol + delta-tocotrienol (TRM) is a nutritional supplement combination being investigated for the management of metabolic syndrome and type 2 diabetes. The formulation typically consists of 250 mg of delta-tocotrienol, often sourced from annatto-derived DeltaGold, and 150 mg of resveratrol. The combination exerts antioxidant and anti-inflammatory effects and has been shown in clinical trials to modulate the expression of specific microRNAs, including the upregulation of miR-130b-5p and miR-221-5p and the downregulation of miR-122-5p. These molecular changes are associated with improvements in central obesity, insulin resistance, and dyslipidemia.
- Other names
- delta-tocotrienol and resveratrol mixture
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)RPSA (37/67 kDa laminin receptor)PGHS-1 (Prostaglandin G/H Synthase 1)
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