retapamulin + mupirocin

Retapamulin + mupirocin refers to the combination of two topical antibiotics, each with a distinct mechanism of action, used primarily for the treatment of skin infections such as impetigo. Retapamulin is a semisynthetic pleuromutilin antibiotic that inhibits bacterial protein synthesis by binding to the 50S subunit of bacterial ribosomes at protein L3 near the peptidyl transferase center, thereby inhibiting peptidyl transferase activity and blocking initiator tRNA binding to the P-site[2][6]. Mupirocin is a naturally occurring antibiotic produced by Pseudomonas fluorescens; it acts by specifically and reversibly inhibiting bacterial isoleucyl-tRNA synthetase, leading to inhibition of protein and RNA synthesis[8]. Both agents are bacteriostatic at lower concentrations but can be bactericidal at higher concentrations or with prolonged exposure. They are effective against Staphylococcus aureus and Streptococcus pyogenes, including strains resistant to other antibiotics[7][8]. These drugs are available only in topical formulations due to their pharmacokinetic properties.

Other names

retapamulin topicalmupirocin calcium