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RG1507 + letrozole
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
RG1507 + letrozole is an investigational **combination therapy** evaluated for advanced breast cancer. **RG1507 (R1507)** is a fully human monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF-1R), aiming to inhibit cancer cell growth driven by this pathway. **Letrozole** is a nonsteroidal aromatase inhibitor that lowers estrogen levels, reducing hormone-driven tumor proliferation. The combination's rationale is to simultaneously block IGF-1R signaling and estrogen production, potentially overcoming resistance to endocrine therapy and enhancing anticancer effects in postmenopausal women with advanced breast cancer[1][7].
- Other names
- RG1507 + letrozoleR1507 + letrozole
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)CYP19A1 (Aromatase)
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